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Anti-Inflammatory Steroids: Are Corticosteroids Useful in Your Practice?
You will receive 1 unit(s) of continuing education credit upon successful completion of this course. The registration fee is only $35.00

This course presents a detailed review of the appropriate use of glucocorticoids for prophylaxis of postoperative swelling and for the treatment of selected inflammatory conditions.



Author:

Daniel Becker, DDS  Show/Hide Bio...



Learning Objectives:

 Upon completion of this course, participants should be able to do the following:

  1. Distinguish physiological and pharmacological effects of the glucocorticoids.
  2. Describe the effects of glucocorticoids on the HPA axis and relate this to the concepts of alternate day-therapy and steroid preps prior to dental treatment.
  3. Discuss side effects and contraindications for steroid use, distinguishing short-term from long-term therapy.
  4. Compare glucocorticoids in terms of potency, efficacy and side effects.
  5. Describe possible indications and regimens for their use in dental practice.

Abstract:

Do you prescribe or administer steroidal agents in your practice? Or do you assume that their adverse effects outweigh any potential benefit? This course will review and update your thinking on the appropriate use of glucocorticoids for prophylaxis of postoperative swelling and for the treatment of selected inflammatory conditions. Contraindications and management of chronically medicated patients also are addressed.




Outline:

COURSE OUTLINE

  1. Overview 

  2. Physiological Considerations

    1. Anti-inflammatory Action

    2. Considerations for Patients

  3. Use of Glucocorticoids in Dentistry

  4. Summary



 


References:
  1. Beirne OR, Hollander B. The effect of methylprednisolone on pain, trismus, and swelling after removal of third molars. Oral Surg Oral Med Oral Pathol. 1986; 61:134-138.
  2. Bracken MB, Shepard MJ, Collins WF, at. al. A randomized controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. N Engl J Med. 1990; 20(322):1405-1411.
  3. Buyukkurt MC, Gungormus M, Kaya O. The effect of a single dose prednisolone with and without diclofenac on pain, trismus, and swelling after removal of mandibular third molars. J Oral Maxillofac Surg 2006; 64(12):1761-6.
  4. Hargreaves KM, Costello A. Glucocorticoids suppress levels of immunoreactive bradykinin in inflamed tissue as evaluated by microdialysis probes. Clin Pharmacol Ther. 1990; 48:168-78.
  5. Mico-Llorens JM, Satorres-Nieto M, Gargallo-Albiol J, Arnabat-Dominguez J, Berini-Aytes L, Gay-Escoda C. Efficacy of methylprednisolone in controlling complications after impacted lower third molar surgical extraction. Eur J Clin Pharmacol 2006; 62(9):693-8.
  6. Montgomery MT, Hogg JP, Roberts DL, Redding SW. The use of glucocorticosteroids to lessen the inflammatory sequelae following third molar surgery. J Oral Maxillofac Surg. 1990; 48:179-187.
  7. Moore PA, Brar P, Smiga ER, Costello BJ. Preemptive rofecoxib and dexamethasone for prevention of pain and trismus following third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 99(2):E1-7.
  8. Olin BR and Hebel SK, editors. Drug Facts and Comparisons. 2009 edition. St Louis: Facts and Comparisons; 2009.
  9. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids- New mechanisms for old drugs.  N Engl J Med 2005;353(16):1711-23.
  10. Schimmer BP, Parker KL. Adrenocorticotropic hormone; Adrenocortical steroids and their synthetic analogs; Inhibitors of the synthesis and actions of adrenocortical hormones. In: Brunton LL, Lazo JS, Parker KL.  Eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th edition. New York: McGraw-Hill, 2006.
  11. Silverman S, et.al. Clinical efficacy of predisone in the treatment of patients with oral inflammatory ulcerative diseases: A study of fifty-five patients. Oral Surg Oral Med Oral Pathol. 1985; 59:360-363.
  12. Sisk AL, Bonnington GJ. Evaluation of methylprednisolone and flurbiprofen for inhibition of the postoperative inflammatory response. Oral Surg Oral Med Oral Pathol. 1985; 60:137-145.
  13. Troullos ES, Hargreaves KM, Butler DP, Dionne RA. Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus. J Oral Maxillofac Surg. 1990; 48:945-52.



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ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.
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