Genetic Risk for Severe Periodontal Disease
You will receive 1 credit(s) of continuing education credit upon successful completion of this course. The purchase price of this course is $49.00


This course discusses the importance of a genetic component to severe periodontal disease.


Learning Objectives:

Upon completion of this course, participants should be able to do the following:

  1. Describe the evidence for the etiology of periodontitis.
  2. Explain the limitations with the current plaque paradigm.
  3. Describe the genetic susceptibility scientific breakthrough.
  4. Identify how the genetic information changes and improves the ability to allocate resources and improve treatment.


The discovery of a genetic marker that is highly associated with increased risk for severe periodontitis is a major breakthrough in the clinical management of all dental patients. The marker is not diagnostic; rather, it is a prognostic test and it is used to identify patients who are much more susceptible to plaque. Individuals who have the marker have a 6 to 19 times higher chance of getting severe periodontitis than those who do not have the marker. It is estimated that 30% of the US population will test positive. This new information supplements existing microbiology and immunology research. A limitation of the established view of the etiology of periodontal disease makes it difficult to explain why certain patients are more or less at risk based solely on their level of oral hygiene. It has also been difficult to predict the clinical outcomes of various treatments for individual patients because each person implements their own oral hygiene differently. The genetic discovery helps to explain why some people with a little plaque have a lot of disease, and why other people with a lot of plaque have only minor problems. By incorporating the constant factor of genetics into your philosophy of practice, the patient's periodontal needs and desires can be better understood and managed.




  1. Introduction 
  2. A Typical Periodontal Case 
  3. The Infectious Disease Paradigm 
    1. The plaque-antiplaque paradigm basis for treatment planning 
    2. The new paradigm 
  4. The History of PST 
  5.  What We Know Today 
    1. Smoking relationship to genotype
  6. Implications for Clinical Practice 
    1. Genotype-negative patients 
    2. Genotype-positive patients
    3. Discussion 
  7. Case Example Revisited 
  8. Summary

  1. Newman MG, ed. Proceedings of the 1996 World Workshop in Periodontics. Chicago: American Academy of Periodontology, 1996.
  2. McGuire MK, Newman MG.  Evidence-based periodontal treatment I. A strategy for clinical decisions. Int J Periodontics Restorative Dent. 1995; 15:71-83..
  3. Newman MG, McGuire MK. Evidence-based periodontal treatment II. Int J Periodontics Restorative Dent 1995; 15:116-127..
  4. Kornman KS, Crane A, Wang H-Y, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodonto. 1997; 24:72-77..
  5. Kornman KS, de Giovine FS: Genetic variations in cytokine expression: a risk factor for severity of adult periodontitis. Annals of Periodontology (in press).

American Dental Association is an ADA CERP Recognized Provider.

ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.